Calocurb (GLP-1 Activator)

 CALOCURB

Calocurb is a clinically validated weight management supplement that helps regulate appetite, reduce cravings, and decrease caloric intake. Its key ingredient, Amarasate®, is a natural extract from New Zealand bitter hops. This extract is encapsulated to stimulate the release of GLP-1, a natural satiety hormone that helps you feel fuller for longer. Studies show it can reduce hunger by up to 30% and calorie intake by 18%.

Key features of Calocurb:

• Clinically proven to reduce appetite by 80% and calorie intake by 18%
• It contains Amarasate®, which stimulates gut tastebuds to release fullness-signaling hormones.
• Plant-based, GMO-free, vegan, and free from sugar, caffeine, and stimulants.
• No injections required

Recommended usage:

• Days 1-2: 1 capsule, 1 hour before a meal
• Days 3-4: 1 capsule twice daily, 1 hour before meals
• Day 5 onward: 2 capsules twice daily, 1 hour before lunch and dinner
• Maximum: 4 capsules daily, always on an empty stomach

Calocurb supports healthy appetite management and may help with overeating. Use it with a balanced diet and regular exercise for best results.

Other ingredients: GMO-Free Canola Oil, Rosemary Leaf Extract, Delayed Release Vegetarian Capsule (Hypromellose)

Understanding the 'Bitter Brake' Effect and Its Discovery

The 'bitter brake' effect finds its roots in historical practices aimed at curbing appetite. Notably, during times of famine, people in the Scottish Highlands would chew on particularly bitter berries to help stave off hunger. Similarly, in the Kalahari Desert, tribesmen relied on bitter cacti during extended hunts to suppress their appetites. This led researchers in New Zealand to explore how such bitter compounds might trigger similar responses, ultimately culminating in discovering the 'bitter brake' effect.

Historical Inspiration:

Historical examples of using bitter compounds to suppress hunger include intriguing cultural practices. In the Scottish Highlands, during times of famine, locals would chew extremely bitter berries to curb their appetites. Similarly, tribesmen in the Kalahari Desert resorted to chewing bitter cactus to stave off hunger during lengthy hunts. These time-tested methods, drawn from nature’s bounty, inspired New Zealand scientists to search for a modern extract that mimics this natural appetite suppression. They developed what is now called the "bitter brake," reflecting these historical influences.

Details and Significance of Clinical Studies on Amarasate

The Amarasate ingredient has been the focus of extensive research, emphasizing its impact on weight management and appetite control. Here’s a detailed overview of the clinical studies showcasing the significance of this compound:

Robust Scientific Foundation

Amarasate has undergone multiple clinical trials, all adhering to high standards such as ethics approval and double-blind, randomized methodologies. These studies ensure the claims on weight loss and appetite suppression are scientifically valid, distinguishing Amarasate in the supplement industry.

Key Findings from Clinical Trials

1. First Human Clinical Study (2019):

   • Design & Participants: A randomized, placebo-controlled trial with 30 healthy men participating in a 24-hour water-only intermittent fast.
   • Dosage & Results: Participants received either 250 mg or 100 mg of Amarasate daily, resulting in a significant hunger reduction—over 10% in both groups and 30% in the higher dose group—demonstrating enhanced satiety for up to four hours.

2. Follow-Up Study:

   • Objective: Explored the real-world effects of Amarasate on calorie intake in healthy men.
   • Procedure: A 500 mg dose was administered to 19 participants to monitor its influence on energy intake.
   • Outcomes: Documented an 18% reduction in calorie consumption and stimulated hormonal responses, namely ghrelin, CCK, GLP-1, and PYY, indicating effective appetite and glycemic regulation.

3. Women-Focused Study:

   • Design & Focus: This randomized, placebo-controlled study targeted 30 women over a 24-hour fast.
   • Findings: Notable appetite and craving reductions (~40%) were recorded, underscoring the ingredient's efficacy during fasting and highlighting its potential gender-specific responses.

Challenges and Findings in Testing Calocurb on Women Across Hormonal Cycles and Menopause

Research into the effects of GLP-1 stimulation in women has uncovered key insights and challenges. One of the primary findings is that women exhibit a higher sensitivity to GLP-1, which leads to a more pronounced decrease in hunger and cravings compared to men. This heightened sensitivity is believed to be an evolutionary trait that could aid in gestational protection.

Hormonal Cycle Considerations

Women’s menstrual cycles add a layer of complexity to testing. During the luteal phase, for instance, there's a tendency to consume up to an additional 600 calories daily. This is a crucial factor to address when considering appetite-regulating supplements. Products like Calocurb can be particularly effective during this phase, helping manage increased appetite and cravings.

Menopause-Related Findings

Similarly, menopause presents another set of challenges. As women go through menopause, their caloric needs change, requiring them to eat approximately 200 calories less each day to maintain their current weight. In this context, utilizing appetite-control products can be advantageous in helping to manage these dietary adjustments without undue hardship.

These findings highlight the importance of timing and individual hormonal cycles when using appetite regulation supplements in women. Understanding these nuances is essential for optimizing effectiveness and ensuring that such products are used to their full potential.

Biological Mechanisms and Effects

The trials indicate that Amarasate influences the release of key hormones involved in appetite suppression. It has been shown to substantially elevate the release of appetite-suppressing hormones, surpassing levels necessary for behavioral change. This aspect is particularly significant as it moves beyond physiological markers to effectuate noticeable dietary behavior changes.

Evolutionary and Gender Insights

Research suggests women exhibit heightened sensitivity to GLP-1 stimulation, a finding that links back to evolutionary factors for fetal protection. This sensitivity means specific application strategies can be developed, such as during certain menstrual phases or menopause, to manage increased calorie intake effectively.

Continued Research and Broader Implications

Ongoing studies, including a large-scale trial with 150 participants over six months, aim to further affirm and expand upon these findings, ensuring the ingredient's benefits are comprehensively understood. This continued investment in research solidifies Amarasate as a pioneering compound in managing hunger and supporting weight management strategies.

These trials collectively highlight Amarasate as a promising, scientifically-backed ingredient capable of facilitating significant reductions in hunger and calorie intake, offering a potential breakthrough in dietary supplements for weight management.

1.  Scientists were inspired by age-old methods of using bitterness to reduce hunger pangs, drawing direct analogies from various cultures around the world.

2. Scientific Exploration: Researchers examined 300 human intestinal biopsies to identify an important aspect of intestinal biology: the presence of TAS2R bitter receptors on entero-endothelial cells. These receptors play a crucial role in detecting bitter substances.

3. Experimentation: Using an innovative cellular model, they tested over a thousand natural extracts to evaluate how these receptors respond.

4. Eureka Moment: Among these extracts, a particular variety of hops stood out as it uniquely activated the TAS2R receptors. This activation led to a substantial release of hormones associated with appetite suppression.

This groundbreaking discovery of the hop extract's effect confirmed the historical anecdotes and laid the foundation for further clinical research. By tapping into these ancient practices, scientists have pioneered a modern approach to managing appetite through natural compounds.

The Potential of Calocurb in Supporting Transitions Off GLP-1 Agonists

For individuals transitioning off GLP-1 agonist drugs, Calocurb may offer a promising solution. As patients move away from these medications, there is often concern about regaining weight due to the loss of appetite regulation provided by the drugs.

Calocurb naturally stimulates the body’s production of hormones like GLP-1 and CCK/PYY. These hormones are crucial in regulating appetite and maintaining the gut-brain connection. By encouraging the body to produce these hormones, Calocurb helps individuals manage their eating habits more effectively.

Additionally, Calocurb can act as a safety net, potentially reducing the risk of weight rebound. For those concerned about maintaining their weight after stopping GLP-1 agonist drugs, Calocurb presents an avenue for continued weight management support.

Research has highlighted notable differences between men and women in their response to GLP-1 stimulation triggered by Amarasate. Women tend to exhibit a heightened sensitivity to this stimulation, experiencing a more pronounced decrease in hunger and cravings than men. This heightened sensitivity is believed to serve an evolutionary purpose, ensuring women consume adequate nutrients to protect a developing fetus.

These variations suggest practical applications for managing dietary intake at different stages of a woman’s life. For instance, during the luteal phase of the menstrual cycle, women may consume up to 600 additional calories daily. In contrast, they might need to reduce intake by around 200 calories daily during menopause to maintain weight. These findings provide insights into tailored dietary strategies based on hormonal cycles and life stages.

The Journey to Discovering Amarasate for Appetite Suppression

Researchers undertook a comprehensive journey to find an effective extract for appetite suppression, focusing their efforts on Amarasate. This began with an extensive screening process to identify the most promising candidate for clinical trials.

Scientific Methodology

1. Initial Research: Researchers conducted a series of 300 biopsies to examine the human intestinal tract. Their goal was to demonstrate the presence of TAS2R bitter receptors on the entero-endothelial cells lining the intestine.

2. Cell Model Development: They developed a model to test TAS2R signaling efficacy using these findings. This model was tested with over 1,000 extracts to evaluate which could stimulate these receptors.

3. Key Discovery: Among the many extracts, a specific hop variety emerged as the crucial discovery. It was the only extract that significantly activated the receptors to release hormones known for suppressing appetite.

This critical discovery laid the foundation for subsequent clinical studies, confirming the potential of Amarasate in managing hunger effectively.

The New Zealand government played a crucial role in the inception and development of Amarasate by funding substantial primary research. Back in 2010, scientists at Plant and Food Research, a government-funded institution, proposed a groundbreaking idea. They aimed to discover a plant-based extract capable of helping control appetite. This initiative, "Foods for appetite control," was backed by significant financial support through a $20 million research grant.

The decision to fund this project was driven by New Zealand's concern over its high obesity rate, which ranks just behind the United States and Mexico globally. The government believed an affordable appetite-controlling food extract could significantly improve public health and yield economic benefits. This strategic investment underscored New Zealand's commitment to addressing obesity and promoting healthier lifestyle choices through scientific innovation.

Calocurb is a clinically validated weight management supplement that helps regulate appetite, reduce cravings, and decrease caloric intake. Its key ingredient, Amarasate®, is a natural extract from New Zealand bitter hops. This extract is encapsulated to stimulate the release of GLP-1, a natural satiety hormone that helps you feel fuller for longer. Studies show it can reduce hunger by up to 30% and calorie intake by 18%.

The discovery of the GLP-1 hormone in 1986 was a groundbreaking moment in the science of appetite regulation. This hormone plays a crucial role in the body's feedback mechanism for controlling eating, and its manipulation has become a focal point in both pharmaceuticals and nutraceuticals. Researchers have explored ways to increase GLP-1 levels naturally or through synthetic means, such as GLP-1 agonist injectables, marking significant advancements in obesity and weight management strategies.

Emerging research highlights that bitter compounds can activate satiety-related hormones like GLP-1. After extensive screening, Amarasate was identified as the most promising candidate for clinical trials focused on appetite suppression. This specific hop extract was the 'eureka' discovery, the only one to significantly stimulate receptors responsible for releasing appetite-suppressing hormones.

The clinical studies conducted have not only yielded statistically significant results but also demonstrated behavioral changes in participants. Notably, these studies have shown that consuming this supplement leads to a 600% increase in the release of appetite-suppressing hormones, far surpassing the levels achieved by other supplements. This elevation is critical, as the literature indicates that a 400% increase is necessary for effective behavioral change in eating habits.

Furthermore, research suggests that women are more responsive to GLP-1 stimulation, experiencing a more significant reduction in hunger and cravings than men. This sensitivity is believed to be an evolutionary trait designed to protect the fetus. These findings underline the potential of gastrointestinal delivery of bitter compounds as an effective method for reducing cravings and managing weight.

Calocurb offers a practical solution for individuals struggling with hunger and cravings, supporting them in making healthier dietary choices. As hunger sensations gradually intensify after reducing calorie intake, this supplement is crucial in countering the body's natural inclination to seek food, driven by the primitive hindbrain's response to perceived famine.

Calocurbis is a clinically validated weight management supplement that helps regulate appetite, reduce cravings, and decrease caloric intake. Its key ingredient, Amarasate®, is a natural extract from New Zealand bitter hops. This extract is encapsulated to stimulate the release of GLP-1, a natural satiety hormone that helps you feel fuller for longer. Studies show it can reduce hunger by up to 30% and calorie intake by 18%.

Key features of Calocurb:

• Clinically proven to reduce appetite by 80% and calorie intake by 18%
• It contains Amarasate®, which stimulates gut tastebuds to release fullness-signaling hormones.

Calocurb's efficacy is backed by rigorous scientific research. Over 14 years and $30 million in funding have gone into developing this supplement, culminating in independent, double-blind, randomized trials published in high-end journals.

Clinical Trials and Findings:

1. Initial Trials: A 2019 study evaluated the effects of Amarasate during a 24-hour water-only intermittent fast. Thirty healthy men received a high (250 mg) or low (100 mg) dose twice daily, significantly reducing hunger by at least 10%. The high-dose group reported a 30% decrease in hunger, enhancing satiety for up to 4 hours.

2. Follow-Up Study: Further research demonstrated that a 500 mg dose could significantly lower calorie intake by 18% in healthy-weight men. The hop extract reduced hunger and activated the release of appetite-regulating hormones such as ghrelin, CCK, GLP-1, and PYY, providing a potential “bitter brake” on energy intake.

3. Recent Findings: A study involving 30 women revealed that those taking either high or low doses of Amarasate® during fasting experienced a roughly 40% reduction in appetite and cravings. This suggests that gastrointestinal delivery of bitter compounds can effectively curb food cravings.

These comprehensive trials highlight Calocurb's unique ability to stimulate hormone release at levels that drive behavioral change, setting it apart from other supplements that may not reach the necessary thresholds.

Calocurb is a clinically validated weight management supplement that helps regulate appetite, reduce cravings, and decrease caloric intake. Its key ingredient, Amarasate, is a natural extract from New Zealand bitter hops. This extract is encapsulated to stimulate the release of GLP-1, a natural satiety hormone that helps you feel fuller for longer. Studies show it can reduce hunger by up to 30% and calorie intake by 18%.

In-Depth Clinical Insights

In a 2019 study published in Nutrients, researchers explored Amarasate's effects during a 24-hour water-only intermittent fast. Thirty healthy men participated, receiving a high (250 mg) or low (100 mg) extract dose twice daily. Remarkably, both groups recorded at least a 10% decrease in hunger. The high-dose group reduced self-reported hunger by 30%, suggesting a single dose can significantly enhance satiety for up to four hours.

A subsequent study further examined Amarasate's impact on subjective hunger and real-world calorie intake. In this trial, 19 healthy-weight men were given either a placebo or 500 mg of Amarasate in delayed-release or regular form. Results indicated an 18% reduction in calories consumed, accompanied by the stimulation of appetite-regulating hormones like ghrelin and PYY. These findings suggest Amarasate could act as a natural 'bitter brake' on energy intake.

Gender-Specific Findings

Earlier this year, research published in Obesity Pillars focused on women, revealing significant appetite and craving reductions of about 40% when taking Amarasate during fasting. This study highlighted that gastrointestinal delivery of the compound effectively reduces cravings, with women experiencing a more pronounced decrease in hunger than men.

These comprehensive studies underscore Amarasate's potential as a natural aid in managing hunger and reducing calorie intake, making it a promising component in weight management strategies.

Warning: Consult your healthcare professional if pregnant, nursing, or taking prescription medications.

*The Food and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease.